History cabinets
The history cabinets are located in the A-line floor 1.
The group responsible for the cabinet project consisted of Anders Lundgren, Björn Boström, Ulla Uhlin, Bror Strandberg, Lars Oreland, Örjan Zetterqvist, Göran Magnusson and Anders Boulonger (responsible designer) with Staffan Eriksson as coordinator.
Anatomical teaching material
Cabinets with a number of anatomical objects used for teaching can be found in the corridor in A1.
Medical development
The cabinet in A5 is devoted to drug development and is based on Carl von Linné and Jöns Jakob Berzelius and their pioneering activities in botany, medicine and chemistry. A short history is presented about the establishment and development of pharmacology and pharmacy in Sweden and Uppsala with presentations of leading resarchers such as Ernst Barany, Robert Fristedt, Carl Petter Thunberg and Carl Gustav Mosander.
An example of the development of the currently widely used ophthalmic drug Xalatan is also presented.
Responsible for the cabinet is Lars Oreland, Department of Pharmacology, Uppsala University.
Structural biology
The cabinet in A7 describes the development of structural biology, where researchers at BMC had a central position. Here, a review is made of the principles for X-ray crystallographic structure determination of proteins, nucleic acids and virus particles. Special emphasis is placed on data collection and structural interpretation past and present. An X-ray precision camera is on display, and examples from structural research projects are presented. The cabinet is produced by the section for structural biology at Uppsala University (ICM) and SLU (MBV). Coordinators: Bror Strandberg and Ulla Uhlin. Text and form: Ulla Uhlin and Anders Boulonger.
Complements to this structural biology cabinet are available in the form of physical models of alcohol dehydrogenase (A11) and satellite tobacco necrosis virus (A9) as well as light images of several molecular models (C11).
Protein chemistry
The cabinet in A8 describes the early protein chemistry in Sweden with the Nobel laureates The Svedberg and Arne Tiselius in focus. Copies but also originals of research material from these two researchers shed light on the early development of methods for studying colloidal particles and proteins by ultracentrifugation and electrophoresis. The purpose is to demonstrate the starting point for the activities that later made Uppsala a world center for biological separation research.
Responsible for the cabinet is Associate Professor Anders Lundgren, Dept. for History of Ideas and Science, Uppsala University and Uppsala University's archives have lent material to the stand.
From basic research to application
The cabinet in A9 describes three BMC-related projects and intends to provide examples of connections between basic research and application. The first example is about hyaluronan. Research on its physical chemistry has been used in the development of Pharmacia's eye surgery product Healon. The second project concerns the anticoagulant heparin. Extensive studies of its structure and its interaction with antithrombin have led to low molecular weight heparin (Fragmin). The third project concerns the Platelet-Derived Growth Factor (PDGF). The finding that PDGF is homologous to a cancer gene product came to be an important reason why a branch of the Ludwig Institute for Cancer Research was relocated to Uppsala and BMC. Knowledge of PDGF and PDGF receptors have been used elsewhere in the development of drugs, such as Glivec, which are used in certain tumor diseases. Responsible for the cabinet is Professor Lena Kjellén.